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Good morning! Today, we learn more about studying tumors at the International Space Station, study the buzzy Amgen weight loss drug MariTide, and find a lawsuit in which a former Spark Therapeutics executive is accusing ex-colleagues of sexism.

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The need-to-know this morning

  • Pfizer appointed Andrew Baum as its new chief strategy and innovation officer. Baum joins Pfizer from the investment bank Citi, where he served as head of global healthcare research. He is joining Pfizer’s executive committee and will report to Chairman and CEO Albert Bourla.
  • In a mid-stage study, EyePoint Pharmaceuticals said its eye drug Duravyu failed to improve disease control compared to a sham injection in patients with non-proliferative diabetic retinopathy.
  • GlycoMimetics said its experimental drug for acute myeloid leukemia failed to achieve the primary goal of a Phase 3 study.
  • Krystal Biotech reported Vyjuvek sales of $45.3 million in the first quarter. Vyjuvek is a topical gene therapy for dystrophic epidermolysis bullosa, an inherited disorder causes painful blisters and persistent wounds.

A deep dive into Amgen’s experimental obesity drug, MariTide

There so much buzz around Amgen’s experimental obesity drug, MariTide. The company simply saying it was “very encouraged” about interim Phase 2 data led to a 12% spike in Amgen’s stock — even though no new data were shared. STAT’s Elaine Chen answers some hot questions about the closely watched injectable.

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